Processing speed and neurodevelopment in adolescent-onset psychosis: cognitive slowing predicts social function.

TitleProcessing speed and neurodevelopment in adolescent-onset psychosis: cognitive slowing predicts social function.
Publication TypeJournal Article
Year of Publication2012
AuthorsBachman, P, Niendam TA, Jalbrzikowski M, Jalbrzikowkski M, Park CY, Daley M, Cannon TD, Bearden CE
JournalJournal of abnormal child psychology
Volume40
Issue4
Pagination645-54
Date Published2012 May
ISSN1573-2835
KeywordsAdolescent, Analysis of Variance, Case-Control Studies, Cognition Disorders, Female, Humans, Male, memory, Mental Processes, Psychiatric Status Rating Scales, Psychomotor Disorders, Psychotic Disorders, Social Adjustment, Vocabulary
Abstract

Onset of psychosis may be associated with abnormal adolescent neurodevelopment. Here we examined the neurocognitive profile of first-episode, adolescent onset psychosis (AOP) as compared to typically developing adolescents, and asked whether neurocognitive performance varied differentially as a function of age in the cases compared with controls. A comprehensive neuropsychological battery was administered to 35 patients experiencing a first-episode of a DSM-IV psychotic disorder and to 31 matched controls. Clinicians also rated subjects' social and role functioning, both at the time of neuropsychological assessment and 1 year later. Although patients displayed a wide range of impairments relative to controls, their most pronounced deficits included verbal memory, sensorimotor dexterity and cognitive processing speed. Among these, only processing speed showed a significant group-by-age interaction, consistent with an aberrant developmental course among AOP patients. Processing speed also accounted for substantial variance in other areas of deficit, and predicted social functioning 1 year later. AOP patients fail to show normal age-related increases in processing speed, which in turn predicts poorer functional outcomes. This pattern is consistent with the view that adolescent brain developmental processes, such as myelination, may be disrupted in these patients.

DOI10.1002/hbm.20991
Alternate JournalJ Abnorm Child Psychol