Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI.

TitleMetabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI.
Publication TypeJournal Article
Year of Publication2010
AuthorsBabikian, T, Marion SD, Copeland S, Alger JR, O'Neill J, Cazalis F, Mink R, Giza CC, Vu JA, Hilleary SM, Kernan CL, Newman N, Asarnow RF
JournalJournal of neurotrauma
Volume27
Issue3
Pagination473-81
Date Published2010 Mar
ISSN1557-9042
KeywordsAdolescent, Age Factors, Aging, Anisotropy, Aspartic Acid, Axons, Biological Markers, Brain Injuries, Child, Choline, Cognition Disorders, Corpus Callosum, Diffuse Axonal Injury, Diffusion Tensor Imaging, Female, Humans, Magnetic Resonance Spectroscopy, Male, Wallerian Degeneration
Abstract

Diffuse axonal injury (DAI) secondary to traumatic brain injury (TBI) contributes to long-term functional morbidity. The corpus callosum (CC) is particularly vulnerable to this type of injury. Magnetic resonance spectroscopy (MRS) was used to characterize the metabolic status of two CC regions of interest (ROIs) (anterior and posterior), and their structural (diffusion tensor imaging; DTI) and neurobehavioral (neurocognitive functioning, bimanual coordination, and interhemispheric transfer time [IHTT]) correlates. Two groups of moderate/severe TBI patients (ages 12-18 years) were studied: post-acute (5 months post-injury; n = 10), and chronic (14.7 months post-injury; n = 8), in addition to 10 age-matched healthy controls. Creatine (energy metabolism) did not differ between groups across both ROIs and time points. In the TBI group, choline (membrane degeneration/inflammation) was elevated for both ROIs at the post-acute but not chronic period. N-acetyl aspartate (NAA) (neuronal/axonal integrity) was reduced initially for both ROIs, with partial normalization at the chronic time point. Posterior, not anterior, NAA was positively correlated with DTI fractional anisotropy (FA) (r = 0.88), and most domains of neurocognition (r range 0.22-0.65), and negatively correlated with IHTT (r = -0.89). Inverse corerlations were noted between creatine and posterior FA (r = -0.76), neurocognition (r range -0.22 to -0.71), and IHTT (r = 0.76). Multimodal studies at distinct time points in specific brain structures are necessary to delineate the course of the degenerative and reparative processes following TBI, which allows for preliminary hypotheses about the nature and course of the neural mechanisms of subsequent functional morbidity. This will help guide the future development of targeted therapeutic agents.

DOI10.3791/1786
Alternate JournalJ. Neurotrauma