Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease.

TitleAssociation of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease.
Publication TypeJournal Article
Year of Publication2004
AuthorsAssal, F, Alarcón M, Solomon EC, Masterman D, Geschwind DH, Cummings JL
JournalArchives of neurology
Volume61
Issue8
Pagination1249-53
Date Published2004 Aug
ISSN0003-9942
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Carrier Proteins, Female, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Polymorphism, Genetic, Receptor, Serotonin, 5-HT2A, Receptors, Serotonin, Serotonin Plasma Membrane Transport Proteins
Abstract

Serotonin has been linked to neuropsychiatric symptoms in Alzheimer disease, mainly agitation/aggression, depression, and psychosis. Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR ) and intron 2 of the serotonin transporter gene (5-HTTVNTR) or the 5-HT2A and 5-HT2C receptor genes in some but not all studies.

DOI10.1038/nn.3115
Alternate JournalArch. Neurol.