Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease.
|Title||Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Assal, F, Alarcón M, Solomon EC, Masterman D, Geschwind DH, Cummings JL|
|Journal||Archives of neurology|
|Date Published||2004 Aug|
|Keywords||Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Carrier Proteins, Female, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Polymorphism, Genetic, Receptor, Serotonin, 5-HT2A, Receptors, Serotonin, Serotonin Plasma Membrane Transport Proteins|
Serotonin has been linked to neuropsychiatric symptoms in Alzheimer disease, mainly agitation/aggression, depression, and psychosis. Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR ) and intron 2 of the serotonin transporter gene (5-HTTVNTR) or the 5-HT2A and 5-HT2C receptor genes in some but not all studies.
|Alternate Journal||Arch. Neurol.|