Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response.

TitleTreatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response.
Publication TypeJournal Article
Year of Publication2009
AuthorsAsarnow, JR, Emslie G, Clarke G, Wagner KD, Spirito A, Vitiello B, Iyengar S, Shamseddeen W, Ritz L, McCracken J, Strober M, Suddath R, Leonard H, Porta G, Keller M, Brent D
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume48
Issue3
Pagination330-9
Date Published2009 Mar
ISSN1527-5418
KeywordsAdolescent, Antidepressive Agents, Second-Generation, Chronic Disease, Cognitive Therapy, Combined Modality Therapy, Cyclohexanols, Depressive Disorder, drug resistance, Female, Fluoxetine, Humans, Male, Paroxetine, Personality Inventory, Prognosis, Serotonin Uptake Inhibitors
Abstract

To advance knowledge regarding strategies for treating selective serotonin reuptake inhibitor (SSRI)-resistant depression in adolescents, we conducted a randomized controlled trial evaluating alternative treatment strategies. In primary analyses, cognitive-behavioral therapy (CBT) combined with medication change was associated with higher rates of positive response to short-term (12-week) treatment than medication alone. This study examines predictors and moderators of treatment response, with the goal of informing efforts to match youths to optimal treatment strategies.

DOI10.1016/j.brat.2011.06.001
Alternate JournalJ Am Acad Child Adolesc Psychiatry