Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response.
|Title||Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Asarnow, JR, Emslie G, Clarke G, Wagner KD, Spirito A, Vitiello B, Iyengar S, Shamseddeen W, Ritz L, McCracken J, Strober M, Suddath R, Leonard H, Porta G, Keller M, Brent D|
|Journal||Journal of the American Academy of Child and Adolescent Psychiatry|
|Date Published||2009 Mar|
|Keywords||Adolescent, Antidepressive Agents, Second-Generation, Chronic Disease, Cognitive Therapy, Combined Modality Therapy, Cyclohexanols, Depressive Disorder, drug resistance, Female, Fluoxetine, Humans, Male, Paroxetine, Personality Inventory, Prognosis, Serotonin Uptake Inhibitors|
To advance knowledge regarding strategies for treating selective serotonin reuptake inhibitor (SSRI)-resistant depression in adolescents, we conducted a randomized controlled trial evaluating alternative treatment strategies. In primary analyses, cognitive-behavioral therapy (CBT) combined with medication change was associated with higher rates of positive response to short-term (12-week) treatment than medication alone. This study examines predictors and moderators of treatment response, with the goal of informing efforts to match youths to optimal treatment strategies.
|Alternate Journal||J Am Acad Child Adolesc Psychiatry|