Moderators, mediators, and other predictors of risperidone response in children with autistic disorder and irritability.

TitleModerators, mediators, and other predictors of risperidone response in children with autistic disorder and irritability.
Publication TypeJournal Article
Year of Publication2010
AuthorsArnold, EL, Farmer C, Kraemer HC, Davies M, Witwer A, Chuang S, DiSilvestro R, McDougle CJ, McCracken J, Vitiello B, Aman MG, Scahill L, Posey DJ, Swiezy NB
JournalJournal of child and adolescent psychopharmacology
Volume20
Issue2
Pagination83-93
Date Published2010 Apr
ISSN1557-8992
KeywordsAdolescent, Autistic Disorder, Biomarkers, Pharmacological, Child, Child, Preschool, Controlled Clinical Trials as Topic, Dopamine Antagonists, Dose-Response Relationship, Drug, Female, Humans, Irritable Mood, Male, Medication Adherence, Risperidone
Abstract

The National Institute of Mental Health (NIMH) Research Units on Pediatric Psychopharmacology (RUPP) Autism Network found an effect size of d = 1.2 in favor of risperidone on the main outcome measure in an 8-week double-blind, placebo-controlled trial for irritability in autistic disorder. This paper explores moderators and mediators of this effect.

DOI10.1016/j.brat.2011.06.001
Alternate JournalJ Child Adolesc Psychopharmacol