Moderators, mediators, and other predictors of risperidone response in children with autistic disorder and irritability.
|Title||Moderators, mediators, and other predictors of risperidone response in children with autistic disorder and irritability.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Arnold, EL, Farmer C, Kraemer HC, Davies M, Witwer A, Chuang S, DiSilvestro R, McDougle CJ, McCracken J, Vitiello B, Aman MG, Scahill L, Posey DJ, Swiezy NB|
|Journal||Journal of child and adolescent psychopharmacology|
|Date Published||2010 Apr|
|Keywords||Adolescent, Autistic Disorder, Biomarkers, Pharmacological, Child, Child, Preschool, Controlled Clinical Trials as Topic, Dopamine Antagonists, Dose-Response Relationship, Drug, Female, Humans, Irritable Mood, Male, Medication Adherence, Risperidone|
The National Institute of Mental Health (NIMH) Research Units on Pediatric Psychopharmacology (RUPP) Autism Network found an effect size of d = 1.2 in favor of risperidone on the main outcome measure in an 8-week double-blind, placebo-controlled trial for irritability in autistic disorder. This paper explores moderators and mediators of this effect.
|Alternate Journal||J Child Adolesc Psychopharmacol|