Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease.

TitleCortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2011
AuthorsApostolova, LG, Hwang KS, Medina LD, Green AE, Braskie MN, Dutton RA, Lai J, Geschwind DH, Cummings JL, Thompson PM, Ringman JM
JournalDementia and geriatric cognitive disorders
Volume32
Issue2
Pagination118-25
Date Published2011
ISSN1421-9824
KeywordsAdult, Alzheimer Disease, Atrophy, Case-Control Studies, cerebral cortex, Female, Genes, Dominant, Heterozygote, Hippocampus, Humans, Male, Middle Aged, Reference Values
Abstract

Both familial and sporadic Alzheimer's disease (AD) result in progressive cortical and subcortical atrophy. Familial autosomal dominant AD (FAD) allows us to study AD brain changes presymptomatically.

DOI10.1038/nn.3115
Alternate JournalDement Geriatr Cogn Disord