Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study.
|Title||Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Altshuler, LL, Bookheimer SY, Townsend J, Proenza MA, Eisenberger N, Sabb F, Mintz J, Cohen MS|
|Date Published||2005 Nov 15|
|Keywords||Adult, Bipolar disorder, Brain Mapping, Female, Frontal Lobe, Gyrus Cinguli, Humans, Inhibition (Psychology), Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Severity of Illness Index, Temporal Lobe|
Patients with bipolar disorder have been reported to have abnormal cortical function during mania. In this study, we sought to investigate neural activity in the frontal lobe during mania, using functional magnetic resonance imaging (fMRI). Specifically, we sought to evaluate activation in the lateral orbitofrontal cortex, a brain region that is normally activated during activities that require response inhibition.
|Alternate Journal||Biol. Psychiatry|