Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study.

TitleBlunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study.
Publication TypeJournal Article
Year of Publication2005
AuthorsAltshuler, LL, Bookheimer SY, Townsend J, Proenza MA, Eisenberger N, Sabb F, Mintz J, Cohen MS
JournalBiological psychiatry
Volume58
Issue10
Pagination763-9
Date Published2005 Nov 15
ISSN0006-3223
KeywordsAdult, Bipolar disorder, Brain Mapping, Female, Frontal Lobe, Gyrus Cinguli, Humans, Inhibition (Psychology), Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Severity of Illness Index, Temporal Lobe
Abstract

Patients with bipolar disorder have been reported to have abnormal cortical function during mania. In this study, we sought to investigate neural activity in the frontal lobe during mania, using functional magnetic resonance imaging (fMRI). Specifically, we sought to evaluate activation in the lateral orbitofrontal cortex, a brain region that is normally activated during activities that require response inhibition.

DOI10.1111/j.1399-5618.2012.01008.x
Alternate JournalBiol. Psychiatry