Acceleration and augmentation strategies for treating bipolar depression.

TitleAcceleration and augmentation strategies for treating bipolar depression.
Publication TypeJournal Article
Year of Publication2003
AuthorsAltshuler, LL, Frye MA, Gitlin MJ
JournalBiological psychiatry
Date Published2003 Apr 15
KeywordsAdrenergic beta-Antagonists, Antidepressive Agents, Antimanic Agents, Antipsychotic Agents, Bipolar disorder, Combined Modality Therapy, Depressive Disorder, Humans, Lithium, Pindolol, Randomized Controlled Trials as Topic, sleep deprivation, Thyroid Hormones

Despite the prevalence and morbidity of bipolar depression, few randomized treatment trials have been conducted to assess clinical efficacy. Even fewer studies have assessed approaches that optimize treatment response for bipolar depression. This review will define three types of common combination strategies--adjunctive, acceleration and augmentation--and discuss the limited literature of controlled studies reported on acceleration and augmentation approaches.

Alternate JournalBiol. Psychiatry