Connecting genes to brain in the autism spectrum disorders.

TitleConnecting genes to brain in the autism spectrum disorders.
Publication TypeJournal Article
Year of Publication2010
AuthorsAbrahams, BS, Geschwind DH
JournalArchives of neurology
Date Published2010 Apr
KeywordsAnimals, Brain, Brain Chemistry, Child, Child Development Disorders, Pervasive, Disease Models, Animal, Gene Expression Regulation, Developmental, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Nervous System Malformations, Phenotype, Social Behavior Disorders

The autism spectrum disorders (ASDs) are a complex group of neuropsychiatric conditions involving language, social communication, and mental flexibility. Here, we attempt to place recent genetic advances within a developmental and anatomical context. Recent progress in identifying ASD candidate genes supports involvement of multiple brain regions, including the frontal lobes, anterior temporal lobes, caudate, and cerebellum. Understanding genetic data within an anatomical context will be critical to explain how individual risk factors operate to shape phenotypic presentation in patients.

Alternate JournalArch. Neurol.