Advances in autism genetics: on the threshold of a new neurobiology.

TitleAdvances in autism genetics: on the threshold of a new neurobiology.
Publication TypeJournal Article
Year of Publication2008
AuthorsAbrahams, BS, Geschwind DH
JournalNature reviews. Genetics
Date Published2008 May
KeywordsAnimals, Autistic Disorder, Gene Dosage, Gene Expression Profiling, Gene Expression Regulation, Genetic Predisposition to Disease, Humans, Oligonucleotide Array Sequence Analysis, Phenotype, Systems Biology

Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility genes and an increased appreciation of the contribution of de novo and inherited copy number variation. Promising strategies are also being applied to identify common genetic risk variants. Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.

Alternate JournalNat. Rev. Genet.