PhoneWork Phone Number: 310-267-5196
AddressWork Address: 4444 Franz HallLos Angeles, CA 90095UNITED STATES
Research Overview: Why is it that our social relationships have such a profound impact on our emotional and physical well-being? Why does feeling connected to those we love feel so good, whereas feeling estranged from them cause so much pain? In my laboratory, we use behavioral, physiological, and neuroimaging techniques to understand how our need for social connection has left its mark on our minds, brains, and bodies. The following are some of the topics that we are currently investigating: The Neural Basis of Social Rejection: When people feel rejected or left out, they often describe their feelings with physical pain words, complaining of ?hurt feelings? or ?broken hearts.? Our research has shown that feeling socially excluded activates some of the same neural regions that are activated in response to physical pain, suggesting that social rejection may indeed be ?painful.? To follow up on this research, we are currently examining the genetic determinants of rejection sensitivity as well as whether the fear of rejection relies on different neural circuitry than the experience of it. The Neural Basis of Social Connection: We all know the feeling that we have when we feel truly connected to someone else. However, we know very little about the neural circuitry that underlies this feeling or the physiological processes that accompany it. We are currently investigating the neural and physiological substrates associated with feeling ?social warmth,? the positive, contented experiential state associated with being in the company of close others. Social Support and Health: Over the past several decades, researchers have repeatedly shown that having social support is beneficial for physical health whereas not having it increases the risk of morbidity and mortality. Although social support is a robust predictor of physical health, comparable to other risk factors such as smoking and high blood pressure, little is known about how social support influences health. In our lab, we use neuroimaging techniques to examine the neural processes that translate perceptions of social support or a lack thereof into the health outcomes that follow.
Meyer Meghan L, Masten Carrie L, Ma Yina, Wang Chenbo, Shi Zhenhao, Eisenberger Naomi I, Han Shihui Empathy for the social suffering of friends and strangers recruits distinct patterns of brain activation. Social cognitive and affective neuroscience, 2013; 8(4): 446-54.
Chester David S, Eisenberger Naomi I, Pond Richard S, Richman Stephanie B, Bushman Brad J, Nathan C The interactive effect of social pain and executive functioning on aggression: an fMRI experiment. Social cognitive and affective neuroscience, 2013; .
Masten Carrie L, Eisenberger Naomi I, Pfeifer Jennifer H, Colich Natalie L, Dapretto Mirella Associations Among Pubertal Development, Empathic Ability, and Neural Responses While Witnessing Peer Rejection in Adolescence. Child development, 2013; 8(4): .
Eisenberger Naomi I Social ties and health: a social neuroscience perspective. Current opinion in neurobiology, 2013; 8(4): .
Muscatell Keely A, Eisenberger Naomi I A Social Neuroscience Perspective on Stress and Health. Social and personality psychology compass, 2012; 6(12): 890-904.
Castle Elizabeth, Eisenberger Naomi I, Seeman Teresa E, Moons Wesley G, Boggero Ian A, Grinblatt Mark S, Taylor Shelley E Neural and behavioral bases of age differences in perceptions of trust. Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(51): 20848-52.
Spunt Robert P, Lieberman Matthew D, Cohen Jessica R, Eisenberger Naomi I The phenomenology of error processing: the dorsal ACC response to stop-signal errors tracks reports of negative affect. Journal of cognitive neuroscience, 2012; 24(8): 1753-65.
Townsend Jennifer D, Bookheimer Susan Y, Foland-Ross Lara C, Moody Teena D, Eisenberger Naomi I, Fischer Jeffrey S, Cohen Mark S, Sugar Catherine A, Altshuler Lori L Deficits in inferior frontal cortex activation in euthymic bipolar disorder patients during a response inhibition task. Bipolar disorders, 2012; 14(4): 442-50.
Eisenberger Naomi I The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. Nature reviews. Neuroscience, 2012; 13(6): 421-34.
Eisenberger Naomi I, Cole Steve W Social neuroscience and health: neurophysiological mechanisms linking social ties with physical health. Nature neuroscience, 2012; 15(5): 669-74.
Muscatell Keely A, Morelli Sylvia A, Falk Emily B, Way Baldwin M, Pfeifer Jennifer H, Galinsky Adam D, Lieberman Matthew D, Dapretto Mirella, Eisenberger Naomi I Social status modulates neural activity in the mentalizing network. NeuroImage, 2012; 60(3): 1771-7.
DeWall C Nathan, Masten Carrie L, Powell Caitlin, Combs David, Schurtz David R, Eisenberger Naomi I Do neural responses to rejection depend on attachment style? An fMRI study. Social cognitive and affective neuroscience, 2012; 7(2): 184-92.
Inagaki Tristen K, Muscatell Keely A, Irwin Michael R, Cole Steve W, Eisenberger Naomi I Inflammation selectively enhances amygdala activity to socially threatening images. NeuroImage, 2012; 59(4): 3222-6.
Chiang Jessica J, Eisenberger Naomi I, Seeman Teresa E, Taylor Shelley E Negative and competitive social interactions are related to heightened proinflammatory cytokine activity. Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(6): 1878-82.
Eisenberger Naomi I The neural bases of social pain: evidence for shared representations with physical pain. Psychosomatic medicine, 2012; 74(2): 126-35.
Inagaki Tristen K, Eisenberger Naomi I Neural correlates of giving support to a loved one. Psychosomatic medicine, 2012; 74(1): 3-7.
Masten Carrie L, Telzer Eva H, Fuligni Andrew J, Lieberman Matthew D, Eisenberger Naomi I Time spent with friends in adolescence relates to less neural sensitivity to later peer rejection. Social cognitive and affective neuroscience, 2012; 7(1): 106-14.
Eisenberger Naomi I, Inagaki Tristen K, Muscatell Keely A, Byrne Haltom Kate E, Leary Mark R The neural sociometer: brain mechanisms underlying state self-esteem. Journal of cognitive neuroscience, 2011; 23(11): 3448-55.
Masten Carrie L, Colich Natalie L, Rudie Jeffrey D, Bookheimer Susan Y, Eisenberger Naomi I, Dapretto Mirella An fMRI investigation of responses to peer rejection in adolescents with autism spectrum disorders. Developmental cognitive neuroscience, 2011; 1(3): 260-70.
Eisenberger Naomi I, Master Sarah L, Inagaki Tristen K, Taylor Shelley E, Shirinyan David, Lieberman Matthew D, Naliboff Bruce D Attachment figures activate a safety signal-related neural region and reduce pain experience. Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(28): 11721-6.
Masten Carrie L, Telzer Eva H, Eisenberger Naomi I An FMRI investigation of attributing negative social treatment to racial discrimination. Journal of cognitive neuroscience, 2011; 23(5): 1042-51.
Masten Carrie L, Morelli Sylvia A, Eisenberger Naomi I An fMRI investigation of empathy for 'social pain' and subsequent prosocial behavior. NeuroImage, 2011; 55(1): 381-8.
Masten Carrie L, Eisenberger Naomi I, Borofsky Larissa A, McNealy Kristin, Pfeifer Jennifer H, Dapretto Mirella Subgenual anterior cingulate responses to peer rejection: a marker of adolescents' risk for depression. Development and psychopathology, 2011; 23(1): 283-92.
Eisenberger Naomi I, Berkman Elliot T, Inagaki Tristen K, Rameson Lian T, Mashal Nehjla M, Irwin Michael R Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biological psychiatry, 2010; 68(8): 748-54.
Townsend Jennifer D, Eberhart Nicole K, Bookheimer Susan Y, Eisenberger Naomi I, Foland-Ross Lara C, Cook Ian A, Sugar Catherine A, Altshuler Lori L fMRI activation in the amygdala and the orbitofrontal cortex in unmedicated subjects with major depressive disorder. Psychiatry research, 2010; 183(3): 209-17.
Slavich George M, Way Baldwin M, Eisenberger Naomi I, Taylor Shelley E Neural sensitivity to social rejection is associated with inflammatory responses to social stress. Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(33): 14817-22.
Dewall C Nathan, Macdonald Geoff, Webster Gregory D, Masten Carrie L, Baumeister Roy F, Powell Caitlin, Combs David, Schurtz David R, Stillman Tyler F, Tice Dianne M, Eisenberger Naomi I Acetaminophen reduces social pain: behavioral and neural evidence. Psychological science, 2010; 21(7): 931-7.
Eisenberger Naomi I, Inagaki Tristen K, Mashal Nehjla M, Irwin Michael R Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain, behavior, and immunity, 2010; 24(4): 558-63.
Moons Wesley G, Eisenberger Naomi I, Taylor Shelley E Anger and fear responses to stress have different biological profiles. Brain, behavior, and immunity, 2010; 24(2): 215-9.
Way Baldwin M, Creswell J David, Eisenberger Naomi I, Lieberman Matthew D Dispositional mindfulness and depressive symptomatology: correlations with limbic and self-referential neural activity during rest. Emotion (Washington, D.C.), 2010; 10(1): 12-24.
Taylor Shelley E, Seeman Teresa E, Eisenberger Naomi I, Kozanian Tamar A, Moore Amy N, Moons Wesley G Effects of a supportive or an unsupportive audience on biological and psychological responses to stress. Journal of personality and social psychology, 2010; 98(1): 47-56.
Masten Carrie L, Eisenberger Naomi I, Pfeifer Jennifer H, Dapretto Mirella Witnessing peer rejection during early adolescence: neural correlates of empathy for experiences of social exclusion. Social neuroscience, 2010; 5(5-6): 496-507.
Master Sarah L, Eisenberger Naomi I, Taylor Shelley E, Naliboff Bruce D, Shirinyan David, Lieberman Matthew D A picture's worth: partner photographs reduce experimentally induced pain. Psychological science, 2009; 20(11): 1316-8.
Eisenberger Naomi I, Inagaki Tristen K, Rameson Lian T, Mashal Nehjla M, Irwin Michael R An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. NeuroImage, 2009; 47(3): 881-90.
Way Baldwin M, Taylor Shelley E, Eisenberger Naomi I Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection. Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(35): 15079-84.
Masten Carrie L, Eisenberger Naomi I, Borofsky Larissa A, Pfeifer Jennifer H, McNealy Kristin, Mazziotta John C, Dapretto Mirella Neural correlates of social exclusion during adolescence: understanding the distress of peer rejection. Social cognitive and affective neuroscience, 2009; 4(2): 143-57.
Lieberman Matthew D, Eisenberger Naomi I Neuroscience. Pains and pleasures of social life. Science (New York, N.Y.), 2009; 323(5916): 890-1.
O'Connor Mary-Frances, Wellisch David K, Stanton Annette L, Eisenberger Naomi I, Irwin Michael R, Lieberman Matthew D Craving love? Enduring grief activates brain's reward center. NeuroImage, 2008; 42(2): 969-72.
Taylor Shelley E, Burklund Lisa J, Eisenberger Naomi I, Lehman Barbara J, Hilmert Clayton J, Lieberman Matthew D Neural bases of moderation of cortisol stress responses by psychosocial resources. Journal of personality and social psychology, 2008; 95(1): 197-211.
Foland Lara C, Altshuler Lori L, Bookheimer Susan Y, Eisenberger Naomi, Townsend Jennifer, Thompson Paul M Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania. Psychiatry research, 2008; 162(1): 27-37.
Eisenberger Naomi I, Gable Shelly L, Lieberman Matthew D Functional magnetic resonance imaging responses relate to differences in real-world social experience. Emotion (Washington, D.C.), 2007; 7(4): 745-54.
Creswell J David, Way Baldwin M, Eisenberger Naomi I, Lieberman Matthew D Neural correlates of dispositional mindfulness during affect labeling. Psychosomatic medicine, 2007; 69(6): 560-5.
Eisenberger Naomi I, Taylor Shelley E, Gable Shelly L, Hilmert Clayton J, Lieberman Matthew D Neural pathways link social support to attenuated neuroendocrine stress responses. NeuroImage, 2007; 35(4): 1601-12.
Lieberman Matthew D, Eisenberger Naomi I, Crockett Molly J, Tom Sabrina M, Pfeifer Jennifer H, Way Baldwin M Putting feelings into words: affect labeling disrupts amygdala activity in response to affective stimuli. Psychological science, 2007; 18(5): 421-8.
Burklund Lisa J, Eisenberger Naomi I, Lieberman Matthew D The face of rejection: rejection sensitivity moderates dorsal anterior cingulate activity to disapproving facial expressions. Social neuroscience, 2007; 2(3-4): 238-53.
Eisenberger Naomi I, Way Baldwin M, Taylor Shelley E, Welch William T, Lieberman Matthew D Understanding genetic risk for aggression: clues from the brain's response to social exclusion. Biological psychiatry, 2007; 61(9): 1100-8.
Eisenberger Naomi I, Jarcho Johanna M, Lieberman Matthew D, Naliboff Bruce D An experimental study of shared sensitivity to physical pain and social rejection. Pain, 2006; 126(1-3): 132-8.
Taylor Shelley E, Way Baldwin M, Welch William T, Hilmert Clayton J, Lehman Barbara J, Eisenberger Naomi I Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biological psychiatry, 2006; 60(7): 671-6.
Taylor Shelley E, Eisenberger Naomi I, Saxbe Darby, Lehman Barbara J, Lieberman Matthew D Neural responses to emotional stimuli are associated with childhood family stress. Biological psychiatry, 2006; 60(3): 296-301.
Altshuler Lori L, Bookheimer Susan Y, Townsend Jennifer, Proenza Manuel A, Eisenberger Naomi, Sabb Fred, Mintz Jim, Cohen Mark S Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study. Biological psychiatry, 2005; 58(10): 763-9.
Lieberman Matthew D, Hariri Ahmad, Jarcho Johanna M, Eisenberger Naomi I, Bookheimer Susan Y An fMRI investigation of race-related amygdala activity in African-American and Caucasian-American individuals. Nature neuroscience, 2005; 8(6): 720-2.
Eisenberger Naomi I, Lieberman Matthew D, Satpute Ajay B Personality from a controlled processing perspective: an fMRI study of neuroticism, extraversion, and self-consciousness. Cognitive, affective & behavioral neuroscience, 2005; 5(2): 169-81.
Eisenberger Naomi I, Lieberman Matthew D Why rejection hurts: a common neural alarm system for physical and social pain. Trends in cognitive sciences, 2004; 8(7): 294-300.
Eisenberger Naomi I, Lieberman Matthew D, Williams Kipling D Does rejection hurt? An FMRI study of social exclusion. Science (New York, N.Y.), 2003; 302(5643): 290-2.
Eisenberger Naomi I, Kemeny Margaret E, Wyatt Gail E Psychological inhibition and CD4 T-cell levels in HIV-seropositive women. Journal of psychosomatic research, 2003; 54(3): 213-24.
Caskey Nicholas H, Jarvik Murray E, Wirshing William C, Madsen Damian C, Iwamoto-Schaap Paula N, Eisenberger Naomi I, Huerta Lorena, Terrace Scott M, Olmstead Richard E Modulating tobacco smoking rates by dopaminergic stimulation and blockade. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2002; 4(3): 259-66.