Michael Irwin

Dr Michael Irwin

Michael Irwin, M.D. holds the Norman Cousins Chair for Psychoneuroimmunology at the UCLA Semel Institute for Neuroscience and Human Behavior and is a Professor of Psychiatry and Biobehavioral Sciences at the UCLA David Geffen School of Medicine. He is Director of the UCLA Cousins Center in Psychoneuroimmunology, Director of the Training Program in Psychoneuroimmunology and Mental Health, and Director of the Inflammatory Biology Core of the Older Adults for Independence Center.


Contact information


Mailing Address:
UCLA Psychr & Biobehav Sci
BOX 957076, 300 Medical Plaza, Ste 3109
Los Angeles, CA 90095
UNITED STATES

Work Address:
Medical Plaza 300, Room 3109
Campus - 707624
Los Angeles, CA 90095
UNITED STATES


Email: mirwin1@ucla.edu

Research Interests

Mind-body and health

His research is broadly based on the interactions between behavior and immunity, with an emphasis on the consequences of major depression on immune processes relevant to infectious disease risk as well as inflammatory disorders. More recently, Dr. Irwin and his colleagues has studied the immunologic and health consequences of insomnia, with evaluation of the reciprocal links between inflammatory cytokines and disordered sleep in clinical populations. His present research program also includes investigations examining the capacity of mind-body interventions to improve insomnia with consequences for inflammatory mechanisms and viral specific immunity in older adults and in cancer survivors

Publications

Motivala SJ, Sarfatti A, Olmos L, Irwin MR Inflammatory markers and sleep disturbance in major depression.. Psychosomatic medicine. . 2005; 67(2): 187-94.
Lesperance F, Frasure-Smith N, Theroux P, Irwin M The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes. Am J Psychiatry. 2004; 161(2): 271-7.
Redwine L, Snow S, Mills P, Irwin M Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expression.. Psychosomatic medicine. . 2003; 65(4): 598-603.
Redwine L, Dang J, Hall M, Irwin M Disordered sleep, nocturnal cytokines, and immunity in alcoholics.. Psychosomatic medicine. . 2003; 65(1): 75-85.
Irwin MR, Pike JL, Cole JC, Oxman MN Effects of a behavioral intervention, Tai Chi Chih, on varicella-zoster virus specific immunity and health functioning in older adults.. Psychosomatic medicine. . 2003; 65(5): 824-30.
O'Connor Mary-Frances, Bower Julie E, Cho Hyong Jin, Creswell J David, Dimitrov Stoyan, Hamby Mary E, Hoyt Michael A, Martin Jennifer L, Robles Theodore F, Sloan Erica K, Thomas Kamala S, Irwin Michael R To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers.. Brain, behavior, and immunity. 2009; 23(7): 887-97.
Weinberg Adriana, Zhang Jane H, Oxman Michael N, Johnson Gary R, Hayward Anthony R, Caulfield Michael J, Irwin Michael R, Clair James, Smith Jeffrey G, Stanley Harold, Marchese Rocio D, Harbecke Ruth, Williams Heather M, Chan Ivan S F, Arbeit Robert D, Gershon Anne A, Schödel Florian, Morrison Vicki A, Kauffman Carol A, Straus Steve E, Schmader Kenneth E, Davis Larry E, Levin Myron J, Levin Myron J Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine.. The Journal of infectious diseases. 2009; 200(7): 1068-77.
Eisenberger Naomi I, Inagaki Tristen K, Rameson Lian T, Mashal Nehjla M, Irwin Michael R An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences.. NeuroImage. 2009; 47(3): 881-90.
Dickerson SS, Gable SL, Irwin MR, Aziz N, Kemeny ME. Social-Evaluative Threat and Proinflammatory Cytokine Regulation: An Experimental Laboratory Investigation.. Psychological science : a journal of the American Psychological Society / APS. 2009; 200(7): .
O'Connor Mary-Frances, Irwin Michael R, Wellisch David K When grief heats up: pro-inflammatory cytokines predict regional brain activation.. NeuroImage. 2009; 47(3): 891-6.
Fuligni Andrew J, Telzer Eva H, Bower Julienne, Irwin Michael R, Kiang Lisa, Cole Steve W Daily family assistance and inflammation among adolescents from Latin American and European backgrounds.. Brain, behavior, and immunity. 2009; 23(6): 803-9.
Cho HJ, Seeman TE, Bower JE, Kiefe CI, Irwin MR. Prospective Association Between C-Reactive Protein and Fatigue in the Coronary Artery Risk Development in Young Adults Study.. Biological psychiatry. 2009; 23(6): .
Irwin Michael R, Olmstead Richard, Valladares Edwin M, Breen Elizabeth Crabb, Ehlers Cindy L Tumor necrosis factor antagonism normalizes rapid eye movement sleep in alcohol dependence.. Biological psychiatry. 2009; 66(2): 191-5.
Irwin MR, Carrillo C, Olmstead R. Sleep loss activates cellular markers of inflammation: Sex differences.. Brain, behavior, and immunity. 2009; 122(12): .
Motivala Sarosh J, Tomiyama A Janet, Ziegler Michael, Khandrika Srikrishna, Irwin Michael R Nocturnal levels of ghrelin and leptin and sleep in chronic insomnia.. Psychoneuroendocrinology. 2009; 34(4): 540-5.
Fuligni Andrew J, Telzer Eva H, Bower Julienne, Cole Steve W, Kiang Lisa, Irwin Michael R A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgrounds.. Psychosomatic medicine. 2009; 71(3): 329-33.
Irwin Michael R, Wang Minge, Ribeiro Denise, Cho Hyong Jin, Olmstead Richard, Breen Elizabeth Crabb, Martinez-Maza Otoniel, Cole Steve Sleep loss activates cellular inflammatory signaling.. Biological psychiatry. 2008; 64(6): 538-40.
O'Connor Mary-Frances, Wellisch David K, Stanton Annette L, Eisenberger Naomi I, Irwin Michael R, Lieberman Matthew D Craving love? Enduring grief activates brain's reward center.. NeuroImage. 2008; 42(2): 969-72.
Miller Andrew H, Ancoli-Israel Sonia, Bower Julienne E, Capuron Lucile, Irwin Michael R Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2008; 26(6): 971-82.
Motivala Sarosh J, Khanna Dinesh, FitzGerald John, Irwin Michael R Stress activation of cellular markers of inflammation in rheumatoid arthritis: protective effects of tumor necrosis factor alpha antagonists.. Arthritis and rheumatism. 2008; 58(2): 376-83.
Irwin MR, Ziegler M Sleep deprivation potentiates activation of cardiovascular and catecholamine responses in abstinent alcoholics.. Hypertension. . 2005; 45(2): 252-7.
Redwine L, Dang J, Irwin M Cellular adhesion molecule expression, nocturnal sleep, and partial night sleep deprivation.. Brain, behavior, and immunity. . 2004; 18(4): 333-40.
Irwin M, Rinetti G, Redwine L, Motivala S, Dang J, Ehlers C Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics.. Brain, behavior, and immunity. . 2004; 18(4): 349-60.
Zautra AJ, Yocum DC, Villanueva I, Smith B, Davis MC, Attrep J, Irwin M Immune activation and depression in women with rheumatoid arthritis.. The Journal of rheumatology. . 2004; 31(3): 457-63.
Irwin MR, Rinetti G Disordered sleep, nocturnal cytokines, and immunity: interactions between alcohol dependence and African-American ethnicity.. Alcohol (Fayetteville, N.Y.) . 2004; 32(1): 53-61.
Kuhlwein E, Hauger RL, Irwin MR Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics. Biol Psychiatry. 2003; 54(12): 1437-43.
Motivala SJ, Dang J, Obradovic T, Meadows GG, Butch AW, Irwin MR Leptin and cellular and innate immunity in abstinent alcoholics and controls.. Alcoholism, clinical and experimental research. . 2003; 27(11): 1819-24.
Irwin M, Clark C, Kennedy B, Christian Gillin J, Ziegler M Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects.. Brain, behavior, and immunity. . 2003; 17(5): 365-72.
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