|Title||Family History and APOE-4 Genetic Risk in Alzheimer's Disease.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Donix, M , Small GW , Bookheimer SY |
|Date Published||2012 Feb 23|
Identifying risk factors for Alzheimer's disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer's disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice.