|Title||Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Sun, D , Phillips L , Velakoulis D , Yung A , McGorry PD , Wood SJ , van Erp TGM , Thompson PM , Toga AW , Cannon TD , Pantelis C |
|Date Published||2009 Mar|
|Keywords||Adolescent , Adult , Brain Mapping , cerebral cortex , Disease Progression , Female , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Male , Personality Inventory , Psychotic Disorders , Reproducibility of Results , Risk , Young Adult |
Schizophrenia and related psychoses are associated with brain structural abnormalities. Recent findings in 'at risk' populations have identified progressive changes in various brain regions preceding illness onset, while changes especially in prefrontal and superior temporal regions have been demonstrated in first-episode schizophrenia patients. However, the timing of the cortical changes and their regional extent, relative to the emergence of psychosis, has not been clarified. We followed individuals at high-risk for psychosis to determine whether structural changes in the cerebral cortex occur with the onset of psychosis. We hypothesized that progressive volume loss occurs in prefrontal regions during the transition to psychosis.
|Alternate Journal||Schizophr. Res.|