|Title||Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Donix, M , Burggren AC , Suthana NA , Siddarth P , Ekstrom AD , Krupa AK , Jones M , Rao A , Martin-Harris L , Ercoli LM , Miller KJ , Small GW , Bookheimer SY |
|Date Published||2010 Oct 15|
|Keywords||Alzheimer Disease , Apolipoprotein E4 , cerebral cortex , Female , Genetic Predisposition to Disease , Heterozygote , Humans , Longitudinal Studies , Magnetic Resonance Imaging , Male , Middle Aged , Polymorphism, Single Nucleotide , Reference Values |
People with the apolipoprotein-Eepsilon4 (APOE-4) genetic risk for Alzheimer's disease show morphologic differences in medial temporal lobe regions when compared to non-carriers of the allele. Using a high-resolution MRI and cortical unfolding approach, our aim was to determine the rate of cortical thinning among medial temporal lobe subregions over the course of 2 years. We hypothesized that APOE-4 genetic risk would contribute to longitudinal cortical thickness change in the subiculum and entorhinal cortex, regions preferentially susceptible to Alzheimer's disease related pathology. Thirty-two cognitively intact subjects, mean age 61 years, 16 APOE-4 carriers, 16 non-carriers, underwent baseline and follow-up MRI scans. Over this relatively brief interval, we found significantly greater cortical thinning in the subiculum and entorhinal cortex of APOE-4 carriers when compared to non-carriers of the allele. Average cortical thinning across all medial temporal lobe subregions combined was also significantly greater for APOE-4 carriers. This finding is consistent with the hypothesis that carrying the APOE-4 allele renders subjects at a higher risk for developing Alzheimer's disease.