We are resequencing neurodegeneration-related genes in a large series of patients with neurodegenerative conditions, including Alzheimer’s Disease (AD), Frontotemporal Dementia (FTD), and Progressive Supranuclear Palsy (PSP), in collaboration with the UCSF Memory and Aging Center , the UCLA Easton Center for Alzheimer’s Research  and other collaborating Institutions. Advances in sequencing technology allow now to sequence the whole genome in patients where causative mutations have not been identified and we are doing that in a subset of our patients. We are also interested in the genetics of neuropsychiatric disorders, including bipolar disorder and Tourette’s Disorder.
We are studying whole-genome expression and methylation data from peripheral blood samples from patients with neurodegenerative dementia. We are using peripheral gene expression data from patients with Friedreich's ataxia and animal models to characterize the effect of compounds with therapeutic potential.
We are developing network-based methods to integrate multiple layers of information, including genetic, genomic, epigenetic, and neuroimaging data.