Research

Previous research addressed the impact of medical illness and cerebrovascular disease, and candidate genes on cognitive and mood disorders in later life that can alter treatment response and serve as risk factors for future dementia. We have a constantly evolving portfolio of projects, and many require volunteers to participate. Please review our list of studies currently looking for participants.

 

Published Research

  • Lavretsky H. Neuropsychiatric symptoms in Alzheimer disease and related disorders: why do treatments work in clinical practice but not in the randomized trials? Am J Geriatr Psychiatry. 2008 Jul;16(7):523-7. 
  • Lavretsky H, Zheng L, Weiner MW, Mungas D, Reed B, Kramer JH, Jagust W, Chui H, Mack WJ. The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia. Int J Geriatr Psychiatry. 2008 Apr 16. 
  • Lavretsky H, Siddarth P, Kumar A, Reynolds CF 3rd. The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study. Int J Geriatr Psychiatry. 2008 Jan;23(1):55-9.
  • Lavretsky H, Ballmaier M, Pham D, Toga A, Kumar A. Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Am J Geriatr Psychiatry. 2007 May;15(5):386-94.
  • Lavretsky H, Nguyen LH. Innovations: geriatric psychiatry: diagnosis and treatment of neuropsychiatric symptoms in Alzheimer's disease. Psychiatr Serv. 2006 May;57(5):617-9.
  • Lavretsky H, Park S, Siddarth P, Kumar A, Reynolds CF 3rd. Methylphenidate-enhanced antidepressant response to citalopram in the elderly: a double-blind, placebo-controlled pilot trial. Am J Geriatr Psychiatry. 2006 Feb;14(2):181-5.
  • Lavretsky H, Roybal DJ, Ballmaier M, Toga AW, Kumar A. Antidepressant exposure may protect against decrement in frontal gray matter volumes in geriatric depression. J Clin Psychiatry. 2005 Aug;66(8):964-7.
  • Lavretsky H, Kurbanyan K, Ballmaier M, Mintz J, Toga A, Kumar A. Sex differences in brain structure in geriatric depression. Am J Geriatr Psychiatry. 2004 Nov-Dec;12(6):653-7.
  • Lavretsky H, Kitchen C, Mintz J, Kim MD, Estanol L, Kumar A. Medical burden, cerebrovascular disease, and cognitive impairment in geriatric depression: modeling the relationships with the CART analysis. CNS Spectr. 2002 Oct;7(10):716-22.
  • Lavretsky H, Ercoli L, Siddarth P, Bookheimer S, Miller K, Small G. Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia. Am J Geriatr Psychiatry. 2003 Nov-Dec;11(6):667-73.
  • Lavretsky H, Bastani R, Gould R, Huang D, Llorente M, Maxwell A, Jarvik L;UPBEAT Collaborative Group. Unified Psychogeriatric Biopsychological Evaluation and Treatment. Predictors of two-year mortality in a prospective "UPBEAT" study of elderly veterans with comorbid medical and psychiatric symptoms. Am J Geriatr Psychiatry. 2002 Jul-Aug;10(4):458-68.
  • Lavretsky H, Kumar A. Clinically significant non-major depression: old concepts, new insights. Am J Geriatr Psychiatry. 2002 May-Jun;10(3):239-55. Review.
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