UCLA Hatos Center for Neuropharmacology,
MacDonald Research Lab,
675 Charles E Young Dr South,
Los Angeles, California 90095

(310) 794-7011

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Christopher Evans, Ph.D. Director

Dr. Chris Evans is currently Director of the UCLA Brain Research Institute and the Stefan Hatos Professor directing the Shirley and Stefan Hatos Center for Neurophamacology in the UCLA Semel Institute. Dr. Evans is also director of a NIH-funded center - The Center for Opioid Receptors and Drugs of Abuse or CSORDA. CSORDA, with continuous NIH funding for over 25 years.

Anne Andrews, Ph.D.

Understanding how the serotonin neurotransmitter system modulates complex behaviors including anxiety, mood, stress responsiveness, and learning and memory.

Arthur Brody, Ph.D.

Treatment and brain function in cigarette smokers. Uses positron emission tomography and magnetic resonance imaging to examine how effective treatments for smoking.

James Boulter

Transgenic mice are used to investigate the molecular neurobiology of nicotinic acetylcholine receptors in nociception, the modulation of mesolimbic-dopaminergic reward pathways, and epilepsy.

Brigitte Kieffer

Research goal is to tackle the role of opioid and related neuropeptide systems in brain physiology and psychiatric disorders and to explore the genetic basis of drug addiction and depression

Timothy J. Hales

Opioid receptor coupling to ion channels is studied using molecular and electrophysiological techniques. Several components of various ion channels have been identified by this laboratory. The role of these ion channels in the actions of drugs of abuse is being examined.

Michael Fanselow, Ph.D.

One of Dr. Fanselow’s major areas of concentration within the Center is how opioids and their receptors regulate emotional learning and help select neural pathways for the learning of fear.

Nigel Maidment, Ph.D.

Mechanisms of reinforcement are studied using in vivo microdialysis and primary culture measurements of monoamine, amino acid and neuropeptide transmitter release combined with behavioral models in both rats and receptor knockout mice.

David Krantz, Ph.D. M.D.

Interested in the molecular mechanisms that regulate synaptic transmission, and the relationship between changes in neurotransmitter release and neuropsychiatric and neurodegenerative illnesses such as addiction, depression and Parkinson’s disease. His laboratory focuses on the function of neurotransmitter transporters, the proteins responsible for transporting neurotransmitters such as dopamine and serotonin across biological membranes.

Bernard Balleine

Interested in the establishing whether and on what basis the classical division of reflex, habit and volition can be maintained, how the sources of these activities differ and how they interact in the neural systems involved in motor, cognitive and emotional functions to determine complex adaptive behavior.

Wendy Walwyn

Interested in novel pain-relieving strategies and targets, focusing on the opioid receptors present in the neurons that relay pain information. As these receptors are regulated and controlled by a 3-dimensional array of kinases and scaffolding proteins in the pre-synaptic terminal of these cells, we examine how such interactions can be manipulated to reduce the sensation of pain.

Xiangdong William Yang, Ph.D.

In the Hatos Center, Dr. Yang focuses on addressing how the BG circuits may control the behaviors related to natural rewards and opioid rewards. Dr. Yang’s laboratory is interested in studying the cortical and basal ganglia (BG) circuitry and molecular mechanisms involved in normal behavioral control and in pathogenesis of neurodegenerative disorders such as Huntington's disease.

Cui-Wei Xie

Effects of opiates and other drugs of abuse on synaptic plasticity, ion channel function and signal transduction are investigated in brain slice preparations and in cultured neurons from hippocampus, DRG and VTA, using electrophysiological approaches (extracellular, intracellular recording and patch-clamping)

Andrew Charles

Dr. Charles research focuses on calcium imaging and cellular signaling as it relates to nociception with an emphasis on systems mediating migraine and headaches. Dr. Charles is a Neurologist specializing in headaches and chronic pain and he is Director of the UCLA Neurology Headache Research and Treatment Program at UCLA.

Anna Taylor
Hoa Lam
Kim LeBlanc
Amynah Pradhan
Kate Wassum, Ph.D.
Polly Segal
Sean Ostlund Assitant Research Neuroscientist