Substance abuse

Substance abuse has come to refer to the overindulgence in and dependence of a drug or other chemical leading to effects that are detrimental to the individual's physical and mental health, or the welfare of others. The disorder is characterized by a pattern of continued pathological use of a medication, non-medically indicated drug or toxin, that results in repeated adverse social consequences related to drug use, such as failure to meet work, family, or school obligations, interpersonal conflicts, or legal problems. There are on-going debates as to the exact distinctions between substance abuse and substance dependence, but current practice standard distinguishes between the two by defining substance dependence in terms of physiological and behavioral symptoms of substance use, and substance abuse in terms of the social consequences of substance use. Substance abuse may lead to addiction or substance dependence. Medically, physiologic dependence requires the development of tolerance leading to withdrawal symptoms. Both abuse and dependence are distinct from addiction which involves a compulsion to continue using the substance despite the negative consequences, and may or may not involve chemical dependency. Dependence almost always implies abuse, but abuse frequently occurs without dependence, particularly when an individual first begins to abuse a substance. Dependence involves physiological processes while substance abuse reflects a complex interaction between the individual, the abused substance and society.

Xanax, OxyContin, and Vicodin overdoses at record highs. Is prescription drug abuse a health epidemic?

Richard Rawson, professor of psychiatry at the Semel Institute and associate director of its Integrated Substance Abuse Programs, was featured Sept. 21 on KPPC-89.3 FM’s Patt Morrison show. He discussed the growing problem of addiction to prescription narcotics, and the fact that drug deaths now outnumber traffic fatalities in the United States.

Drugs Inc.

Edythe London, professor of psychiatry at the Semel Institute, was featured in a July 11 National Geographic program that examined illegal drug abuse in America. London’s segment focused on her research into understanding the biological basis of methamphetamine addiction.

Maximizing effectiveness of medication treatments for addictive disorders

Psychiatry Grand Rounds

The J Thomas Ungerleider, MD, Lecture on Substance Abuse
Maximizing effectiveness of medication treatments for addictive disorders
Timothy Fong MD
Co-Director, UCLA Gambling Studies Program
Director, UCLA Addiction Medicine Clinic
Director, UCLA Addiction Psychiatry Fellowship
Assistant Clinical Professor of Psychiatry David Geffen School of Medicine at UCLA

NEW--Podcast Preview available on the website, www.psychiatrygrandrounds.com

Event detail
22 Jun 2010 - 11:00 - 12:30
Overview

THE UCLA TRANSLATIONAL NEUROSCIENCE OF DRUG ABUSE (TNDA)

is set forth to link several successful UCLA research centers by establishing

a unified training program in the area of translational neurobiology.

 

INFORMATION for PREDOCTORAL APPLICANTS:

Successful Trainees of this Program Receive:

  • First-hand experience in conducting all levels of drug abuse research including: evidence-based hypothesis formation, experimental design, data acquisition and analyses, preparation and presentation of findings for national and international conferences;
  • Expert training, resources and guidance from mentors that will enable trainees to use preliminary data to generate novel hypotheses and specific aims for NIH grant proposals;
  • (Predoctoral Trainees Only) Portion of tuition and fees as funding allows (approximately $5,000)
  • Monthly stipend (As set by NIH: NOT-OD-11-067)
  • Travel Funds ($1,000)

 

TNDA Trainees will select a primary research concentration in 1) Animal Models and Molecular & Cellular Neurobiology, 2) Brain Imaging and Cognitive Neuroscience, or 3) Preclinical Pharmacology and Medications Testing.  Trainees will carry out a research project in a TNDA mentor’s laboratory (listed below), but will gain exposure to other areas of drug abuse research through laboratory rotations, common core training elements as well as by formal and informal interaction among TNDA faculty.

 

Director/Instructor(s): 
Edythe London
Director/Instructor(s): 
James David Jentsch
Director/Instructor(s): 
James Boulter
Director/Instructor(s): 
Christopher Evans
Director/Instructor(s): 
Michael Fanselow
Director/Instructor(s): 
Nelson Freimer
Director/Instructor(s): 
David Krantz
Director/Instructor(s): 
Nigel Maidment
Director/Instructor(s): 
Kelsey C. Martin
Director/Instructor(s): 
Yi Sun
Director/Instructor(s): 
Cui-Wei Xie
Director/Instructor(s): 
Xiangdong William Yang
Director/Instructor(s): 
Robert Bilder
Director/Instructor(s): 
Marco Iacoboni
Director/Instructor(s): 
Javier Quintana
Director/Instructor(s): 
Michael Irwin
Director/Instructor(s): 
Steven Shoptaw
Director/Instructor(s): 
Arthur Brody

Just saying "No" - enhancing cognitive control in substance use disorders

Psychiatry Grand Rounds

 

Just saying "No" - enhancing cognitive control in substance use disorders
J. David Jeṅṫsch, PhD
Professor of Psychology and Psychiatry and Biobehavioral Sciences
Associate Director for Research, Brain Research Institute
University of California, Los Angeles

 

NEW--Podcast Preview available on the website, www.psychiatrygrandrounds.com

 

Event detail
2 Mar 2010 - 11:00 - 12:30
Overview

INFORMATION for POSTDOCTORAL FELLOW APPLICANTS:

Successful Trainees of this Program Will:

  • Conduct an experiment under the mentorship of a TNDA Faculty Member                       
  • Receive the integrative knowledge base needed to plan, conduct and obtain independent funding (R-Series Grants, K-Awards) for bidirectional translational studies of drug abuse.         
  • Be awarded a monthly stipend, basic health insurance (as set by NIH: NOT-OD-11-067) & $1000 travel award.

TNDA Postdoctoral Fellows will select a primary research concentration in 1) Animal Models and Molecular & Cellular Neurobiology, 2) Brain Imaging and Cognitive Neuroscience, or 3) Preclinical Pharmacology and Neuroscience.  Fellows will carry out their research project in a TNDA mentor’s laboratory (below), but will gain exposure to other areas of drug abuse research through laboratory rotations, common core training elements as well as by formal and informal interaction among TNDA faculty.

Below are the names of the TNDA Program Faculty.  All Instructors with links are affiliated with the UCLA Semel Institute/Department of Psychiatry.  The External Instructors are UCLA professors that are not affiliated with the Semel Institute/Department of Psychiatry, but have academic appointments in other relevant areas of study (i.e., Neurology, Psychology, Pharmacology, etc.) but are still members of the TNDA Program Faculty.

Director/Instructor(s): 
Edythe London
Director/Instructor(s): 
James David Jentsch
Director/Instructor(s): 
Christopher Evans
Director/Instructor(s): 
Michael Fanselow
Director/Instructor(s): 
Nelson Freimer
Director/Instructor(s): 
David Krantz
Director/Instructor(s): 
Nigel Maidment
Director/Instructor(s): 
Kelsey C. Martin
Director/Instructor(s): 
Yi Sun
Director/Instructor(s): 
Cui-Wei Xie
Director/Instructor(s): 
Xiangdong William Yang
Director/Instructor(s): 
Robert Bilder
Director/Instructor(s): 
Michael Irwin
Director/Instructor(s): 
Steven Shoptaw
Director/Instructor(s): 
Arthur Brody

Progress in the Management of Opiate Use Disorders

Psychiatry Grand Rounds

 

Progress in the Management of Opiate Use Disorders

Karen A Miotto, MD

Associate Clinical Professor of Psychiatry David Geffen School of Medicine at UCLA

 

NEW--Podcast Preview available on the website, www.psychiatrygrandrounds.com

 

Event detail
12 Jan 2010 - 11:00 - 12:30
Overview

The UCLA Integrated Substance Abuse Programs (ISAP) is organizationally located within the Semel Institute, a division of the UCLA Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine. Because of the complex nature of drug abuse, training in this field combines substantive, methodological, and practical approaches to research. 

The Institutional Training Grant (ITG) Program is a NIDA funded program to provide training to predoctoral and postdoctoral fellows. The grant provides a modest stipend to each trainee, depending on the length of time from your degree.

We employ a multi-disciplinary training program. Cross-disciplinary knowledge is needed to understand drug abuse etiology, behavior, consequences, and treatment. Substantive topics range from psychopharmacology to the social consequences of drug legislation. The variety of research approaches applicable to an understanding of drug abuse include experimental, quasi-experimental, survey, and naturalistic or ethnographic methods. Further, the unique nature of drug abuse data frequently requires new and creative analytic approaches such as specialized methods for analyzing non-normal data, quantifying data collected through qualitative methods, or merging qualitative and quantitative data. Other requirements include working with large databases and collecting data from drug-dependent populations.

Conducting drug abuse research also requires attention to the practical problems of carrying out a study, such as dealing with issues of confidentiality and ethics, and working with federal, state, and local agencies. Investigators must be prepared for and know how to deal with the compromises that must frequently be made between the requirements of an "ideal" research design and the constraints and difficulties imposed by programs and people in the real world. Furthermore, because of the complexities inherent in this type of research, researchers need to learn up-to-date computer methods of statistical analysis to enhance their own efficiency and make costly data more readily available. Finally, researchers need to develop competent writing and communication skills to disseminate research results effectively.

Each fellow is responsible for his or her own training experience, both in terms of process and outcomes, and is expected to be a self-motivated, adult learner. A wide variety of research training resources are available at ISAP and the larger UCLA community; it is anticipated that fellows will actively seek out and utilize these resources according to individual need and interest. To this end, research training activities may vary widely among fellows reflecting different levels of expertise and experience in drug abuse research methods, and specific areas of interest. Although certain coursework and evaluative components of the training program are relatively fixed, the individual trainee is encouraged to structure his or her research training experience in ways consistent with professional development and career goals.