John Ringman, M.D., M.S.
Interim Director, Easton Center for Alzheimer's Disease Research
Associate Clinical Professor Department of Neurology at UCLA
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In one of the first studies of its kind, UCLA researchers used a unique brain scan to assess the levels of amyloid plaques and neurofibrillary tangles — the hallmarks of Alzheimer's disease — in adults with Down syndrome. Published in the June edition of the Archives of Neurology, the finding may offer an additional clinical tool to help diagnose dementia in adults with Down syndrome, a genetic disorder caused by the presence of a complete or partial extra copy of chromosome 21.
A Sept. 17 story in USA Weekend described potential ways to prevent Alzheimer’s disease and cited a UCLA study finding that older adults with little Internet experience were able to trigger key centers in the brain that control decision-making and complex reasoning after just one week of surfing the Web. Dr. Gary Small, Parlow-Solomon Professor on Aging, a professor of psychiatry with the Semel Institute and director of the UCLA Center on Aging, was quoted.
Brain, Behavior, and Aging Research Center
We are a research group investigating Alzheimer's disease (AD) and other dementias. We use neuroimaging procedures, such as PET and MRI, to understand how the brain is changed in dementia. We also test memory and other thinking skills, and interview our patients to understand what types of emotional problems they are having (such as depression or irritability). We combine all of this information to help us understand the symptoms of dementia and the brain changes that contribute to the illness.
Our lab is also involved in treatment studies. In these experiments, we prescribe medication(s), and then test patients to understand how the drug is helping. We are conducting clinical trials both for FDA approved medications and for a new investigational drug to treat AD.