Sertraline (Zoloft) for the Treatment of Depression in Vascular Dementia

Study Detail

We are investigating the safety and effectiveness of sertraline (Zoloft), an antidepressant, in treating the depressive symptoms suffered specifically by people who have vascular dementia. In addition, we are using brain imaging to examine whether these clinical improvements can be associated with changes in brain anatomy and function.

 

Currently we are recruiting patients with vascular dementia and depression.

Project: 
Sertraline (Zoloft) for the Treatment of Depression in Vascular Dementia
More information and application
Target audience: 

You must:

  • Be over the age of 60
  • Have a caregiver who either lives with you or visits you at least 4 times a week
Pre-conditions: 

You must:

  • Have diagnoses of vascular dementia AND depression
  • Otherwise be generally healthy
  • NOT have taken antidepressants within 3 days of starting the study
Involvement: 

Your involvement in the study lasts about 12 weeks and consists of 5 study visits, during which you will:

  • Be given medication (Sertraline) free of charge
  • Receive imaging scans (MRI & PET) of your brain
  • Be interviewed and tested on your memory and thinking
  • Receive $50.00 compensation upon completion
Contact details: 

(310) 268-3043

Neuro.research.va@gmail.com

Review and Approval
Renewal Date: 
2011, January 12

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