Project summary

The UCLA OCD Research Program is looking for people with Obsessive Compulsive Disorder (OCD) to take part in a study providing these possible benefits:

  • Free Diagnostic Evaluation
  • 4 weeks free Cognitive-Behavioral Therapy (non-drug psychotherapy)
  • Free MRI/MRSI Brain Scans
  • Free Neurocognitive Testing


Do you have Obsessive-Compulsive Disorder?

  • Have thoughts or fears that don’t make sense but still make you feel bad?
  • Have to check or do things over and over again?
  • Wash excessively or avoid touching things for fear of contamination?


Purpose of the Study

The purpose of this project is to determine what, if any, changes in brain chemistry and brain structure take place in adults as a result of Cognitive-Behavioral Therapy, a form of non-drug psychotherapy, for OCD. We will measure amounts and distribution of the neurotransmitter chemical glutamate in the brain using MRSI (Magnetic Resonance Spectroscopic Imaging) scans before and after 4 weeks of CBT.  Another purpose is to determine if treatment improves certain cognitive abilities.


You may be eligible for this study if you…

  • Have no history of bipolar disorder, a psychotic disorder, or substance dependence
  • Are in good physical health
  • Have not already had more than 30 hours of Cognitive-Behavioral Therapy for OCD
  • Are right-handed
  • Between the ages of 18 and 65
  • Either not taking psychiatric medications or on a stable dose of a serotonin reuptake inhibitor (only) for at least 12 weeks


For more information about the study call

(310) 206-0468 or email csheen@mednet.ucla.edu

Primary Investigator: 
Joseph O'Neill
Primary Investigator: 
Jamie Feusner
Susanna Chang, Ph.D.
Jennifer Levitt, M.D.

For more information on physicians and services at UCLA, please call our Physician Referral Service at (800) UCLA-MD1 or (310) 825-2631. For UCLA Neuropsychiatric and Behavioral Services, contact our ACCESS Center at (800) 825-9989 or (310) 825-9989.

Service available Monday to Friday, 8 a.m. to 5 p.m. (PST) to assist you.

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